3 keywords, read the US National Microbiome

2016-05-16 | Mr. Zealous |

Yesterday to today, my circle of friends was swiped by the news that the US White House initiated the National Microbiome Program.

This is a big event in the field of microbiome, which may reach a total of US $ 521 million in government and private investment, which is by far the largest investment in this field.

I feel very excited, when I shared the news with friends, I briefly commented :

NMI, National Microbiome Initiative, the US National Microbiome Initiative is launched. The White House is $ 121 million, the private is $ 400 million, $ 521 million, and more than 3 billion yuan. The Chinese microbiome plan continues in the foreseeable future? Both science and industry must continueCrying to death?

In the field of microbiome research, the United States leads the world. As a member of the industry, I really cannot help but hope that China will be able to see such exciting news as soon as possible :

China's action should be faster, government support must be in place, and practitioners must also work hard. In the field of microbiome research and application, I personally feel that the gap between China and the United States is still large, and there is no optimistic imagination.

Actually, it ’s not just “optimism without imagination”, I ’m a bit pessimistic. The related research in China originally had the opportunity to break through, but now because of impetuousness and copper smell, it has become more and more backward, more and more backward,More and more backward.


Fortunately, there are a lot of data in American big plans that will be open to the world. At least, this "microbiome enthusiast" will have something to see and science to write.

So, although many articles have introduced the American grand plan very clearly, I still want to use three keywords to talk about my understanding on this special day :

① Pattern

The contents to be studied by the National Microbiome Plan are all-encompassing, but the three major goals are concise and crucial :

Encourage interdisciplinarity, develop platform technology and encourage data sharing, and strengthen talent training.

These three descriptions seem a bit trivial, but it's not easy to do them. Let's take a look at what Americans have prepared for these three goals today :

Since 2000, the National Science Foundation and the United States Department of Agriculture have supported the "Joint Microbial Genome Sequencing Project" for 10 consecutive years;

Since 2007, the National Institutes of Health has launched the Human Microbiome Project for 10 years. At present, about 50,000 sequencing and other genomic data have been shared, and nearly 75,000 researchers in 178 countries have benefited.Here, a total of $ 215 million was spent, of which $ 50 million was spent between 2012 and 2014 alone.

In 2012-2014, the National Institutes of Health invested 19 million U.S. dollars in 19 institutes and research centers to study diabetes, obesity, cardiovascular disease, autism, asthma, cancer, premature birth,The relationship between brain development and behavior and human microorganisms.

In addition, there are more than a dozen related projects and plans that have flourished in the past ten years.

In this way, the White House can launch N government departments that can approve money, more than 100 government agencies, colleges, hospitals, and enterprises in just one year to launch the national microbiome plan.

It can be imagined that more than five billion US dollars will be spent mainly in the next two years. It will definitely be able to issue many high-level research papers and create a lot of valuable data.

Specifically, the word "tools" appears 17 times in the fact sheet specially issued by the White House for this purpose. We can predict that new tools and new methods for microbiome research will appear in large numbers, we knowMicrobiological means will become more convenient and cheaper.

And the American people are more generous in sharing scientific data, so these five billion yuan may also help China's microbiome research and application have a good development.

Let ’s look forward to the new "inverse" results, and look forward to one step closer to the truth of life.

Uh ⊙o⊙ ... Why do I say the word "inverse" again?

② Tolerance

The White House has specially organized a press conference for this national microbiome project. It looks really tall!

And if you look at their fact sheet carefully, you will find that this big plan is still in addition to its grand structure.

Inclusiveness, not only a variety of projects, but also a wide range of benefits for the world and the universe, as well as tolerance for business organization innovation, to give some examples :

University of Michigan, it will cost US $ 3.5 million for undergraduates to play the "Michigan Microbiology Project"! 3.5 million, US $, undergraduates! Uh ⊙o⊙ ... Which Chinese university can provide 3.5 million yuan for undergraduatesHave fun? Amitabha ~

Bill and Melinda Gates are definitely two of the most generous local tyrants in the world. Their foundation has become the most funded private institution in the US National Microbiome Program, $ 100 million! They are very loving, this100 million knife, a considerable part will be used to study malnutrition of children in backward areas, sub-Saharan African crop-related microorganisms and other charitable research. Amitabha, good and good!

Special photo tribute :

NASA, the National Aeronautics and Space Administration, it will cost US $ 12.5 million, of which US $ 10 million will be used in a project called "Sea World" for OMG. Why is it called "Sea World"? I reallyIt ’s a mystery. Also, thank NASA for its generosity, Amitabha, for the microorganisms that may be on other planets.

C3 Jian, a pharmaceutical company, throws $ 75 million to develop safe and effective pathogen-specific antibiotics. In the current era of broad-spectrum antibiotics becoming increasingly unseen, precise guidance can target specific microorganismsThe drug will be cool and how many people will benefit it, Amitabha.

The famous Mayo Clinic is planning to give 1.4 million US dollars to the personalized medicine center. Although not too much, the plan itself may solve the big problem: it needs to combine whole genome sequencing, drug resistance analysis, metagenomic analysis, target environmentTests and 16S rRNA tests; combined with their own developed faecal transplantation and various new methods; combined with diet, nutritional supplements and probiotics. Hospitals are in action, patients are healthier, Amitabha.

Metabiomics company will spend 23.5 million US dollars to study how to analyze the biomarkers of the microbiome from the stool to better detect colon polyps and colorectal cancer. There was Colonguard company, and the existing Metabiomics company, who can actually pass the stool testWhat about a breakthrough in non-invasive detection of colorectal cancer? Let us wait and see, Amitabha!

Replete Biotics company, ready to invest 35,000 US dollars, uh, 30,000 US dollars, you are not mistaken, it is the smallest investment in the more than 500 million US dollars plan to develop a better device for collecting poop.Look, as long as you have good ideas, the $ 35,000 project can also be included in the White House Science Plan, which is so wayward, Amitabha.

I don't know if the above examples can be used to explain "tolerance", but my feeling is like this, and there is no better word, so I just expressed it like this.

In short, the National Microbiome Program has a wide range of concerns, in addition to the United States, but also in Africa; in addition to human symbiotic microorganisms, there are soil, ocean, plant-related microorganisms, and even alien microorganisms.

Finally, a fun one: Rutgers University will spend $ 3.7 million to attract chair professors and 4 new researchers to join. Among the many universities and institutes participating in the microbiome project, Rutgers University is one of them.One family, not much 3.7 million, why just say this is fun?

Uh ⊙o⊙ ... I'll tell you secretly, this 3.7 million US dollars may attract a Chinese bull.

Did I know too much ...

③ Legacy

Mr. Obama will step down next year. Many of the things he has done in the past two years are said to have left a "political legacy". These five major plans in the field of life sciences are indeed a big deal, presumably they can stay in historyNext.

Congratulations to Mr. Obama, and also to the American scientists who are about to "divide up" billions of US dollars. When many researchers are worried about funding, those who can participate in these five science programs will beYears and days will still be easy.

And since it is a legacy, are there any limitations?

Of course! Like the other four major research projects, the US National Microbiome Project may also have a certain show component.

The government sets up a platform of $ 121 million, and even if it does not do so, how can the US government spend tens of millions of dollars on microbiological research every year. Now the related research funding is integrated,In a certain limit, it exceeds the original annual investment, but because "packaging" has become a big science, it seems to have formed a brand-new big project. Is there anything to be said about this?

The 400 million people mobilized by the people are publicly convened for one year. Finally, the relevant inputs of public welfare funds, enterprises, hospitals, etc. are added up and listed together. Many of these money were originally planned.It is necessary to invest, and such a sum of statistics, it feels a bit like China's local government statistics on the amount of investment invitations?

So, the Obama administration still has a sense of showing on big science projects.

So, Chinese scientists, do n’t be too arrogant, do n’t always think that the state ’s investment is not enough, we have a gap from the United States, but the more than 500 million US dollars they “packaged” are not entirely new investment.

If the Chinese government wants to do this, it may also be possible to formulate several sensational scientific plans. It is not difficult to achieve a momentum of more than 973, 863, and the 13th Five-Year Plan. It is just that the actual situation varies from country to country, and China itselfProbably the best way to find it.

As for how to do microbiome research in China, whether there is a Chinese microbiome plan, these may not be what I and other "microbiome lovers" can, but I dare to say a few words :

I can see that some researchers are more impetuous. When the overall research and their own research are not deep enough, they are already stained with copper. This may determine that the country will avoid paying taxes when considering policy formulation.Human money goes to researchers supported by commercial companies.

A big scientific research project has an essential basis for having enough powerful scientists. Unfortunately, there is not enough Chinese cattle in the microbiome field, and there are no characters who can truly unite limited researchers. In front of big opportunities, the individual ability is not enough.The whole is still loose, it really makes me look anxious!

Conversely, the launch of the National Microbiology Program in the United States must be inseparable from the concerted efforts of many big cows. They called for the "Joint Microbiology Program" in Science, and there were close to 20 topOf microbiological research experts participated in the joint report, and finally realized.

And Chinese scientists, we can see that Mr. Zhao Liping of Shanghai Jiaotong University has published a paper in Nature magazine calling for global microbiome cooperation, and has been calling for the "Chinese National Microbiome Project". Unfortunately, except for Mr. Zhao, Not many scholars responded.

So, where to go from here?

Maybe we can start from a less expensive direction, as explained by Dr. Zhang Zhigang from the Kunming Institute of Zoology, Chinese Academy of Sciences?

You can read the article "Zhang Zhigang: How can I do microbiome research without burning money?"

Maybe, Dr. Han Chunyu from Hebei University of Science and Technology has given us great inspiration. We can rely on personal ability and resources to break through first?

Perhaps, Chinese companies can give a little bit more power and use commercial resources to promote scientific progress, such as the achievements of Huada Gene in the Human Intestinal Metagenome Project MetaHIT?

Perhaps it is time for everyone to join forces to support Teacher Zhao Liping's visit?

Perhaps Mr. Zealous is back to scientific research? Uh ⊙o⊙ ...

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Mr. Zealous
Founder of Enthusiastic Bowel Research Institute, Tsinghua Life Science and Medical Alumni Association, Secretary-General of Health blogger, headline article author

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