What are the secrets of microorganisms and cancer?

On December 14, 2019, the MIT Technology Review published the 2019 list of "Innovators Under 35 China" in China. In this list, although it is missing"Entrepreneurs", but we have seen many winners who adhere to scientific research missions in areas with industrial potential, and we have seen more scientists scattered in top academic institutions overseas, with their unswerving efforts and persistence,The scientific research achievements that have achieved world-class benchmarking achievements, of which more than half of the winners have achieved world-class breakthrough research results and discoveries. We will issue exclusive interviews with 35 winners one after another to introduce their technologyInnovation achievements and experiences, as well as their understanding and judgment of technological trends.

About Innovators Under 35 China list

Since 1999, MIT Technology Review has launched a list of “35 people under 35 innovating in science and technology” every year, aiming to select the most talented, innovative, and most talented people worldwide.The 35 young technology innovators or entrepreneurs that may change the world are divided into five categories: inventors, entrepreneurs, visionaries, humanistic carers and pioneers. In 2017, the list was officially launched in China to select nationalitiesYoung technology innovators. The new 2020 list is soliciting nominations and registrations, and the deadline is June 30, 2020. For details, please see the end of the article.

Golden Orange


Golden Orange has been awarded the MIT Technology Review's "35 Technology Innovations Under 35" China Award in 2019 by virtue of a series of achievements in the field of microbiology and cancer treatment.

Age when winning: 34 years old

Position at the time of the award: Assistant Professor, Department of Oncology, University of Pennsylvania School of Oncology Reason for the award: She unveiled the hidden interaction between the immune system, inflammation, and tumors, combining theoretical breakthroughs and new clinical targets.

Microbes are everywhere. They may be in the air, soil, flowing water, all the external environments you are in contact with, even in your body and organs. Microbes are always involved in your life activities, even affecting your emotions and thinking., To influence the development of cancer.

An assistant professor from the University of Pennsylvania School of Medicine, Jin Orange Orange is working to unravel the hidden interaction between the immune system, inflammation and tumors. Her outstanding research work has not only brought theoretical breakthroughs to the basic research of many major diseases.It also provides new important targets for clinical treatment.

Growing up in Tsinghua Garden from a young age, a good educational atmosphere has cultivated Jin Orange Orange's strong interest in natural sciences and the ability to think independently. During his PhD at Yale University, a world-renowned university, Jin Orange Orange studied international immunity.Professor Richard Flavell, an academic authority, has participated in many cutting-edge and pioneering research projects.

During his PhD, through research on the role of the inflammasome pathway inflammatory body in various diseases, Golden Orange discovered for the first time that AIM2 inflammasome can damage the intestinal tract and hematopoietic system by identifying double-stranded DNA damage-mediated radiation.; Abnormal calcified crystals in the joints of patients with osteoarthritis can activate NLRP3 inflammasome, leading to inflammation and tissue degradation; NLRP6 inflammasome is essential for maintaining the homeostasis of the intestinal flora, and defects in this pathway can cause intestinal floraDisorders, which in turn promote obesity, metabolic syndrome, and even colorectal cancer.

Later, she entered the MIT International Oncology Authority Tyler Jacks Laboratory for postdoctoral research. Her main research content was the interaction between the microbial population and the immune system in an attempt to answer the link between it and lung cancer.

Lung cancer is a malignant lung tumor that can be roughly divided into small cell cancer and non-small cell cancer. In 2012, approximately 1.8 million people worldwide contracted new lung cancer and caused 1.6 million deaths. Lung cancer is the most common in menCauses of death from cancer are second only to breast cancer among women.

Traditional treatment methods include surgery, radiotherapy, chemotherapy, etc., the process is painful and long, not only the society but also the heavy burden on the family. And the research of Golden Orange is likely to provide unexpected treatment for some lung cancer in the future "Trick ".

In research, Golden Orange found that growing tumors will change the type and number of bacteria in the lungs, stimulate the immune system to produce an inflammatory environment, and then help tumor cells reproduce and accelerate cancer progression.

And antibiotics and antagonists of various inflammatory factors can inhibit lung cancer very effectively. This breakthrough discovery provides new ideas for the prevention and treatment of lung cancer with the highest incidence in the world.

At the same time, the research carried out by Golden Orange also includes the combination of single-cell RNA sequencing and multi-dimensional immunofluorescence imaging technology to explore the temporal and spatial changes of immune cells during tumor growth.At the same time, she is also focusing on research and development for lungGene-edited novel liposome nanoparticles.

At present, Golden Orange Orange has set up its own independent laboratory at the University of Pennsylvania, focusing on how the immune system and microbial community regulate the tumor microenvironment, which in turn affects the development of cancer and the effect of cancer treatment.

In the future, she hopes to further reveal the molecular and cellular mechanisms of the interaction between local flora and the immune system in lung cancer, so as to provide new drug targets for the treatment of lung cancer. At the same time, by changing the local flora to combine existing cancer patientsTargeted drugs or immunotherapy to further improve the survival rate of lung cancer patients.

Speaking of the current development of China's scientific and technological innovation model, Jin Orange Orange said that developing basic science and mastering core technologies is still the top priority. Based on this, expand frontier areas, carry out extensive cooperation, and finally complete clinical transformation.

Basic scientific research and theoretical research deserve more investment. Just like sharpening swords in ten years, we can achieve a sharp edge.

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